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Thermo Fisher Scientific: Applications Scientist Iii, Cell And Gene Therapy R&D

Thermo Fisher Scientific

This is a Contract position in Carlsbad, CA posted January 13, 2021.

Job DescriptionJob Title: Applications Scientist III, Cell and Gene Therapy R& D Thermo Fisher Scientific Inc. is the world leader in serving science, with annual revenue exceeding $25 billion. Our Mission is to enable our customers to make the world healthier, cleaner and safer. Whether our customers are accelerating life sciences research, solving complex analytical challenges, improving patient diagnostics and therapies or increasing productivity in their laboratories, we are here to support them. When you are part of the team at Thermo Fisher Scientific, you’ll do important work, like helping customers in finding cures for cancer, protecting the environment or making sure our food is safe. Your work will have real-world impact, and you’ll be supported in achieving your career goals. Location and Division Specifics The Cell & Gene Therapy R&D team focuses on developing and improving products and workflows to meet customers’ needs. Working together with R& D teams from other disciplines ensures an energetic and fast paced environment to drive collaboration and scientific curiosity. How will you make an impact? This position requires a talented and motivated scientist to support cell and gene therapy product development initiatives. The role will focus on building cell and gene therapy relevant workflows integrating new cell processing and gene delivery platforms. Work includes both ex vivo and in vivo gene delivery and genetic engineering of primary T cells, NK cells and hematopoietic stem cells with viral and non-viral platforms. The ideal candidate will also have knowledge and experience in closed automated systems, cell therapy process development and clinical manufacturing. Additionally, it is expected that this individual will be able to work collaboratively with other scientists and cross-functional project team members including engineers, product management, marketing and commercial team to support the development and launch of new products. What will you do? * Critically design, plan and independently execute experiments, * Isolation, expansion and maintenance of human immune cells including T cells, NK cells and other relevant cell types * Execute experiments using automated cell therapy instrument platforms * Optimize ex vivo gene delivery protocols to maximize gene editing in immune cells and stem cells * Some in vivo gene delivery into mouse models with viral vectors * Perform analytical assays including identity and potency assays as well as complex multi-color flow cytometry experiments to characterize and validate cell types of interest * Work collaboratively with other R& D colleagues and productapplication scientist to integrate newly developed cell processing and gene delivery platforms to develop closed automated workflows * Actively working with cross functional team to identify new cell and gene therapy product and workflow automation opportunities * Build and maintain good lab notebooks, protocols and SOPs How will you get here? * Ph. D in cell biology, immunology or relevant life sciences field with 1-2 years or Masters with 3-5 years of relevant industry experience * 3+ years of immune cells and at least 1-2 years of cell therapy instrument platform is required. * Experience in viral or non-viral genetic modification is preferred. * Extensive cell analysis and characterization assay experience especially with immune cells and stem cells with minimum 2 years multicolor flow cytometry * Demonstrate a sense of urgency with a can-do attitude to take on new tasks * Self-starter with strong work ethic and ability to work independently in a fast-paced team environment, * Must have excellent organizational skills, attention to detail, verbal and written communication * Highly developed presentation skills to communicate results and needs to both internal and external team members At Thermo Fisher Scientific, each one of our 75,000 extraordinary minds have a unique story to tell. Join us and contribute to our singular mission enabling our customers to make the world healthier, cleaner and safer. Apply today! Thermo Fisher Scientific is an EEO/Affirmative Action Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability or any other legally protected status